Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Using family studies to understand comorbidity

P J Wickramaratne1, M M Weissman

  • 1Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

European Archives of Psychiatry and Clinical Neuroscience
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Depression and cognition are associated with lipid dysregulation in both a multigenerational study of depression and the National Health and Nutrition Examination Survey.

Translational psychiatry·2024
Same author

Genetic effects influencing risk for major depressive disorder in China and Europe.

Translational psychiatry·2017
Same author

Polygenic interactions with environmental adversity in the aetiology of major depressive disorder.

Psychological medicine·2015
Same author

The effects on children of depressed mothers' remission and relapse over 9 months.

Psychological medicine·2014
Same author

Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing.

Molecular psychiatry·2013
Same author

Genotyping serotonin transporter polymorphisms 5-HTTLPR and rs25531 in European- and African-American subjects from the National Institute of Mental Health's Collaborative Center for Genomic Studies.

Translational psychiatry·2013

This study introduces a family study design to investigate psychiatric disorder comorbidity. It analyzes patterns of transmission to understand the relationship between conditions like panic disorder and major depressive disorder.

Area of Science:

  • Psychiatry
  • Genetics
  • Epidemiology

Background:

  • Comorbidity between psychiatric disorders is common.
  • Understanding the familial nature of comorbidity is crucial for effective treatment.
  • Panic disorder and major depressive disorder frequently co-occur.

Purpose of the Study:

  • To describe methods for investigating the comorbidity of familial psychiatric disorders using family studies.
  • To develop statistical approaches for testing comorbidity models.
  • To explore the relationship and causes of comorbidity between panic disorder and major depressive disorder.

Main Methods:

  • Utilizing a family study design with four proband groups: pure forms of each disorder, comorbid form, and controls.
  • Classifying disorders in relatives to mirror proband categories.

Related Experiment Videos

  • Applying statistical methods to analyze transmission patterns and test comorbidity hypotheses.

    • Main Results:

    • The described methods allow for the investigation of comorbidity patterns in familial psychiatric disorders.
    • Statistical analyses can formally test various hypotheses regarding the nature of comorbidity.
    • Application to panic disorder and major depressive disorder data provides insights into their relationship.

    Conclusions:

    • The proposed family study methodology is effective for dissecting the nature of psychiatric disorder comorbidity.
    • This approach aids in understanding the genetic and environmental influences contributing to co-occurring disorders.
    • Further research using these methods can refine diagnostic and therapeutic strategies for comorbid conditions.