Fluconazole: pharmacokinetics and indications

Fluconazole is a new systemic azole antifungal agent, with the imidazole group substituted by a triazole, presenting a decrease in lipophilicity, soluble in water, weakly bound to plasma proteins, and a wide range of formulations. The time to reach steady-state with a once daily dosage is approximately 7 days. Distribution of fluconazole is extensive and even throughout the tissues, and the drug circulates as a free drug. Half-life elimination is approximately 30 h. Indications are given for fungal infections in AIDS patients and mycoses.