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Related Experiment Videos

Chemopreventive drug development: perspectives and progress

G J Kelloff1, C W Boone, J A Crowell

  • 1Chemoprevention Investigational Studies Branch, National Cancer Institute, Bethesda, Maryland 20892.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|January 1, 1994
PubMed
Summary

Chemoprevention research focuses on developing safe and effective agents to prevent cancer. This involves identifying early disease markers and testing various drugs and combinations across different clinical trial phases.

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Area of Science:

  • Oncology
  • Pharmacology
  • Preventive Medicine

Background:

  • Chemoprevention aims to identify safe and effective agents for clinical cancer prevention.
  • Key strategies include validating early disease markers, exploring mechanisms of action, and evaluating drug combinations.
  • A systematic methodology is crucial for ranking candidate agents and optimizing resource allocation.

Purpose of the Study:

  • To review drugs and drug combinations that have reached advanced stages of chemopreventive agent development.
  • To categorize these agents based on their developmental phase (first, second, and third generation).

Main Methods:

  • Discussion of 22 drugs and 3 drug combinations in advanced development.
  • Categorization into three generations based on clinical trial phase (Phase II/III, Phase I, preclinical).

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Main Results:

  • First-generation drugs (Phase II/III) include retinoids, calcium, beta-carotene, tamoxifen, and finasteride.
  • Second-generation drugs (Phase I) include 2-difluoromethylornithine, sulindac, piroxicam, and others.
  • Third-generation agents (preclinical) show promise in animal models, including S-allyl-I-cysteine, curcumin, and others.

Conclusions:

  • Multiple chemopreventive agents are progressing through development, with some in late-stage clinical trials.
  • Combinations of agents are also being investigated to enhance efficacy and reduce toxicity.
  • Continued research and systematic development are essential for discovering optimal chemopreventive strategies.