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The study of histamine H1- and H2-receptors in human lung cancer
T Y Kondratenko1, I V Zacharova, Katukov VYu
1Research Center of Molecular Diagnostics and Therapy, Moscow, Russia.
Biochemistry and Molecular Biology International
|November 1, 1993
Abstract:
Data on human lung histamine H1- and H2-receptors in cancer and chronic inflammatory processes are reported. It has been found that the number of histamine H1-receptors significantly increases both in cancer and chronic pneumonia and does not practically change in tuberculosis lung parenchyma. The binding parameters of histamine H2-receptors both in cancer and inflammatory processes were similar to those obtained for the normal tissue. The important role of parenchymal histamine H1-receptors in the neuromodulation of airways in human lung adenocarcinoma is discussed.