Related Experiment Videos
A contribution to immunological tumour diagnostics in urology
International Urology and Nephrology
|January 1, 1978
Summary
The electrophoretic mobility (EM) test detects lymphocyte sensitization to detect malignant tumors. This method accurately confirmed histological diagnoses for kidney, bladder, and prostate cancers.
Area of Science:
- Urology
- Oncology
- Immunology
Background:
- Malignant diseases of the urinary bladder and prostate require accurate diagnostic methods.
- Lymphocyte sensitization is a potential indicator of malignancy.
Purpose of the Study:
- To evaluate the diagnostic utility of the electrophoretic mobility (EM) test for detecting lymphocyte sensitization in patients with urinary bladder and prostate diseases.
- To assess the effectiveness of the EM test in confirming histological tumor diagnoses using tumor-associated antigens (TAA).
Main Methods:
- Fifty-four patients with malignant and other diseases of the urinary bladder and prostate were examined.
- The electrophoretic mobility (EM) test was employed to assess lymphocyte sensitization.
- Antigens from brain tissue (EF) and from malignomas of the kidney, urinary bladder, and prostate were utilized.
Main Results:
- Positive results were observed in 40 out of 42 patients with malignant tumors.
- Five out of 12 patients with other kidney diseases also showed positive results.
- The EM test, using corresponding tumor-associated antigens (TAA), confirmed the histological tumor diagnosis in all cases.
Conclusions:
- The EM test demonstrates high sensitivity in detecting lymphocyte sensitization associated with malignant diseases of the urinary bladder and prostate.
- Positive findings using both EF and corresponding TAA are highly indicative of a malignant disease.
- The EM test serves as a valuable tool for confirming histological tumor diagnoses in urological cancers.