Comparison of cone-mediated electroretinograms obtained before and after vincristine chemotherapy

Vincristine has been shown to reduce the amplitude of postreceptoral electroretinographic components in the isolated arterially perfused cat eye. We examined whether a similar effect occurs in vincristine chemotherapy. In the three patients tested, cone-mediated electroretinograms recorded before and after vincristine chemotherapy were not different. This observation is likely to reflect the lower doses of vincristine used therapeutically.