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Aminoglycoside resistance patterns of Serratia marcescens strains of clinical origin

R Coria-Jiménez1, C Ortiz-Torres

  • 1Laboratorio de Bacteriología, Instituto Nacional de Pediatría, Delegación Coyoacan, México, D.F.

Epidemiology and Infection
|February 1, 1994
PubMed

Insights

Aminoglycoside resistance in Serratia marcescens clinical strains varied by institution and time. A significant increase in aminoglycoside-resistant strains was observed, suggesting selection pressures.

Area of Science:

  • Microbiology
  • Antimicrobial Resistance
  • Clinical Bacteriology

Background:

  • Serratia marcescens is an opportunistic pathogen.
  • Aminoglycosides are crucial antibiotics for treating Gram-negative infections.
  • Monitoring antimicrobial resistance patterns is vital for effective treatment strategies.

Purpose of the Study:

  • To investigate the aminoglycoside resistance patterns of clinical Serratia marcescens isolates.
  • To identify variations in resistance based on isolation time and location.
  • To assess the prevalence of aminoglycoside resistance over a 12-year period.

Main Methods:

  • Analysis of 147 clinical Serratia marcescens strains.
  • Characterization of bacterial populations and resistance profiles.
  • Correlation of resistance patterns with study periods and isolation institutions.

Main Results:

  • Significant correlations found between resistance patterns, study periods, and institutions.
  • Predominant resistance patterns included ACC(6')-I and ANT(2'') + AAC(6')-I.
  • A marked decrease in aminoglycoside-sensitive strains was observed at the National Institute of Pediatrics over 12 years.

Conclusions:

  • Institutional and temporal factors influence Serratia marcescens aminoglycoside resistance.
  • Evidence suggests selection for highly aminoglycoside-resistant Serratia marcescens strains.
  • Ongoing surveillance is necessary to track evolving resistance trends.

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