Intussusception, adenovirus, and children: a brief reaffirmation

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E A Montgomery1, E J Popek

  • 1Department of Pathology, Georgetown University, Washington, DC 20007.

Human Pathology
|February 1, 1994
PubMed

Insights

Pediatric intussusception cases revealed lymphoid hyperplasia as a common cause. Adenovirus infection was identified in 31.2% of these cases, particularly in younger patients with fatal outcomes.

Area of Science:

  • Pediatric Pathology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Intussusception is a significant cause of bowel obstruction in children.
  • Identifying the underlying etiology is crucial for effective management and prognosis.

Purpose of the Study:

  • To investigate the pathological causes of intussusception in pediatric patients.
  • To determine the association of lymphoid hyperplasia and viral infections, specifically adenovirus, with intussusception.

Main Methods:

  • Analysis of 63 pediatric surgical and autopsy specimens with intussusception.
  • Histopathological examination, including immunohistochemistry for adenovirus.
  • Serological testing for Yersinia species.

Main Results:

  • Lymphoid hyperplasia was the leading cause in 51% of cases.
  • Adenovirus infection was identified in 31.2% of cases with lymphoid hyperplasia.
  • Younger patients experienced more fatal outcomes, but adenovirus infection was not a distinguishing factor.

Conclusions:

  • Lymphoid hyperplasia is a primary driver of pediatric intussusception.
  • Adenovirus is a notable co-factor in a significant subset of these cases.
  • While intussusception can be fatal, particularly in infants, adenovirus presence did not correlate with mortality in this cohort.

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