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Effect of ginger on platelet aggregation in man
S K Verma1, J Singh, R Khamesra
1Department of Medicine & Indigenous Drug Research Centre, RNT Medical College, Udaipur.
The Indian Journal of Medical Research
|October 1, 1993
Summary
Dietary butter intake significantly increased platelet aggregation in healthy males. However, ginger supplementation effectively inhibited this butter-induced platelet aggregation, suggesting a protective effect against thrombosis.
Area of Science:
- Nutrition Science
- Cardiovascular Physiology
- Pharmacology
Background:
- Dietary fats can influence hemostasis.
- Platelet aggregation plays a key role in thrombosis.
- Natural compounds are explored for cardiovascular health benefits.
Purpose of the Study:
- To investigate the effect of dietary butter on platelet aggregation.
- To evaluate the potential inhibitory effect of ginger on butter-induced platelet aggregation.
Main Methods:
- Healthy male volunteers were supplemented with butter for 7 days.
- Platelet aggregation was measured in response to adenosine diphosphate (ADP) and epinephrine.
- Ginger or placebo was administered with a fatty meal in a controlled study.
Main Results:
- Butter supplementation significantly enhanced platelet aggregation (P < 0.001).
- Ginger administration significantly inhibited ADP- and epinephrine-induced platelet aggregation (P < 0.001).
- Serum lipid levels remained unchanged in both butter and ginger groups.
Conclusions:
- Dietary butter intake can promote a pro-thrombotic state by enhancing platelet aggregation.
- Ginger exhibits significant anti-platelet activity, counteracting the effects of dietary fat.
- Ginger may be a beneficial dietary intervention for cardiovascular health.