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Cyclothialidine, a novel DNA gyrase inhibitor. I. Screening, taxonomy, fermentation and biological activity
J Watanabe1, N Nakada, S Sawairi
1Nippon Roche Research Center, Kanagawa, Japan.
The Journal of Antibiotics
|January 1, 1994
Abstract:
Streptomyces filipinensis NR 0484 produced a new DNA gyrase inhibitor, cyclothialidine. It showed potent activity against DNA gyrases from Escherichia coli and Micrococcus luteus.