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Related Experiment Videos

Beta-cyclodextrin as a direct compression excipient compared to conventional ones

S I Saleh1

  • 1Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Egypt.

Journal De Pharmacie De Belgique
|September 1, 1993
PubMed
Summary

Beta-cyclodextrin shows promise as a direct compression excipient. Studies indicate it possesses favorable physical and compression properties for tablet manufacturing.

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Journal de pharmacie de Belgique·1993

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Direct compression is an efficient tablet manufacturing method.
  • Excipients play a crucial role in direct compression tablet quality.

Purpose of the Study:

  • To evaluate beta-cyclodextrin as a direct compression excipient.
  • To compare its properties against conventional excipients.

Main Methods:

  • Physical properties (particle size, flowability, density, hygroscopicity) were measured.
  • Compression characteristics (compactibility, force-hardness profiles) were assessed.
  • Tablets were manufactured via direct compression and evaluated for weight uniformity, disintegration, strength, and friability.

Main Results:

  • Beta-cyclodextrin exhibited suitable physical properties for direct compression.
  • Its compression characteristics were comparable to conventional excipients.
  • Tablets produced demonstrated acceptable quality attributes.

Conclusions:

  • Beta-cyclodextrin is a viable candidate for direct compression excipient applications.
  • Further research may explore its use in specific pharmaceutical formulations.

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