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Bromocriptine-induced schizophrenia

S A Peter1, A Autz, M L Jean-Simon

  • 1Department of Medicine, St Mary's Hospital of Brooklyn, New York 11213.

Journal of the National Medical Association
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

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Low-dose bromocriptine therapy for macroprolactinoma induced schizophrenia in a patient with no prior history of psychosis. Symptoms resolved after medication discontinuation, supporting the dopamine hypothesis of schizophrenia.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Endocrinology

Background:

  • Schizophrenia is a complex psychiatric disorder with multifactorial etiology.
  • Macroprolactinomas are pituitary tumors that secrete prolactin, often treated with dopamine agonists like bromocriptine.

Observation:

  • A 53-year-old male, with no previous psychotic episodes, was initiated on low-dose bromocriptine for a macroprolactinoma.
  • Within 4 days of starting bromocriptine, the patient developed symptoms consistent with schizophrenia.

Findings:

  • The patient's psychotic symptoms completely resolved within 5 days of discontinuing bromocriptine.
  • This temporal relationship suggests a causal link between bromocriptine and the onset of schizophrenia in this individual.

Implications:

Related Experiment Videos

  • This case provides further support for the dopamine hypothesis of schizophrenia, suggesting that dopaminergic dysregulation can precipitate psychosis.
  • Clinicians should be vigilant for potential neuropsychiatric side effects when prescribing dopamine agonists, particularly in susceptible individuals.