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Vitamin E in tardive dyskinesia: time course of effect after placebo substitution
L A Adler1, E Peselow, E Duncan
1Psychiatry Service, New York Department of Veterans Affairs Medical Center (DVAMC), NY 10010.
Psychopharmacology Bulletin
|January 1, 1993
Abstract:
Alpha-tocopherol (vitamin E) has been found to be effective in the treatment of tardive dyskinesia (TD). Studies to date have been short in duration and have not found long-term carryover effects of vitamin E. The present study examined the persistence of the effects of vitamin E after longer term (36-week) treatment was discontinued. Vitamin E significantly improved TD over this period. However, the effects of vitamin E persisted so that TD scores approached baseline only after 12 weeks of placebo substitution.