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[Chronic eosinophilic pneumonia or Carrington's disease]

J Durieu1, B Wallaert, A B Tonnel

  • 1Service de Pneumologie et Immuno-allergologie, Hôpital Albert-Calmette, CHRU de Lille.

Revue Des Maladies Respiratoires
|January 1, 1993
PubMed
Summary

Chronic eosinophilic pneumonia (CEP) is an inflammatory lung condition affecting middle-aged women. Diagnosis involves characteristic lung infiltrates and eosinophilia, with rapid response to corticosteroids but frequent relapses.

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Area of Science:

  • Pulmonology
  • Pathology

Context:

  • Chronic eosinophilic pneumonia (CEP) is a rare inflammatory lung disease.
  • First described by Carrington in 1969, it predominantly affects middle-aged women.
  • Characterized by respiratory symptoms and peripheral eosinophilia.

Purpose:

  • To summarize the key features, diagnosis, and management of chronic eosinophilic pneumonia.
  • To differentiate CEP from other lung disorders with similar presentations.

Summary:

  • CEP presents with fever, weight loss, fatigue, and dyspnea, often with diffuse, peripherally located alveolar infiltrates on imaging.
  • Peripheral blood eosinophilia is observed in 90% of cases, alongside eosinophilic alveolitis.
  • Pulmonary function tests typically reveal a restrictive pattern with reduced DLCO and hypoxemia.

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  • Diagnosis is confirmed by lung biopsy showing eosinophilic accumulation and sometimes bronchiolitis obliterans.
  • Differential diagnoses include cryptogenic organizing pneumonia and tuberculosis.

    • Impact:

    • Rapid resolution with corticosteroid therapy is typical, though relapses occur frequently.
    • Approximately 20-30% of patients develop steroid dependence.
    • Understanding CEP is crucial for accurate diagnosis and effective management of this interstitial lung disease.