Related Experiment Videos
Biochemical markers of bone turnover
1INSERM Unit 234 and University C. Bernard, Hôpital E. Herriot, Lyon, France.
Summary
Accurate bone turnover assessment is crucial for osteoporosis diagnosis. Serum osteocalcin and urinary pyridinoline are currently the most sensitive markers for vertebral osteoporosis in women.
Area of Science:
- Biochemistry
- Orthopedics
- Endocrinology
Background:
- Noninvasive assessment of bone turnover is increasingly important for osteoporosis investigation.
- Accurate markers are needed to detect subtle bone metabolism abnormalities.
Purpose of the Study:
- To review current noninvasive markers for bone turnover.
- To identify sensitive markers for osteoporosis assessment.
Main Methods:
- Review of existing studies on bone turnover markers.
- Analysis of markers for bone formation (alkaline phosphatase, osteocalcin, collagen peptides) and resorption (urinary calcium, hydroxyproline, pyridinium cross-links, tartrate-resistant acid phosphatase).
Main Results:
- Markers show variable sensitivity and specificity.
- Serum osteocalcin and urinary pyridinoline are the most sensitive markers for vertebral osteoporosis.
- Combined bone mass measurement and marker assessment are being developed for menopause.
Conclusions:
- A combination of specific markers may improve assessment of metabolic bone diseases like osteoporosis.
- Further development of convenient assays and new markers is ongoing.