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Immunohistochemical detection of c-myc protein in head and neck tumors
M Gapany1, Z P Pavelic, D J Kelley
1Department of Otolaryngology-Head and Neck Surgery, College of Medicine, University of Cincinnati, Ohio.
Objectives:
To evaluate the correlation between the levels of immunohistochemically detectable c-myc protein in squamous cell carcinoma of the head and neck and clinicopathologic prognostic variables utilized in clinical practice.
Design:
Cohort study.
Setting:
University and Veterans Administration medical centers, Cincinnati, Ohio.
Patients Or Other Participants:
Consecutive samples.
Intervention:
Surgery for squamous cell carcinoma of the head and neck.
Main Outcome Measure:
Correlation between c-myc expression and tumor size, nodal involvement, clinical disease stage, and degree of differentiation. Hypothesis formulated after data collection.
Results:
Significant negative correlation between the c-myc levels and the number of metastatic nodes (P = .0001) and clinical stage of disease (P = .05). No correlation with tumor size or degree of differentiation.
Conclusions:
Reduction or loss of c-myc oncoprotein might be associated with metastatic lymph node involvement and advanced stages of squamous cell carcinoma of the head and neck. Further studies are needed to substantiate preliminary findings.
