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Updated: Jul 30, 2026

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Solid-state NMR and IR for the analysis of pharmaceutical solids: polymorphs of fosinopril sodium
H G Brittain1, K R Morris, D E Bugay
1Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903.
Abstract:
The two polymorphic modifications of fosinopril sodium have been characterized as to their differences in melting behaviour, powder X-ray diffraction patterns, Fourier transform infrared spectra (FTIR), and solid-state 31P- and 13C-NMR spectra. The polymorphs were found to be enantiotropically related based upon melting point, heat of fusion, and solution mediated transformation data. Analysis of the solid-state FTIR and 13C-NMR data indicated that the environment of the acetal side chain of fosinopril sodium differed in two polymorphs, and that there might be cis-trans isomerization about the C6-N peptide bond. These conformational differences are postulated as the origin of the observed polymorphism.
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