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Evaluation of two new liquid-liquid oxygenators
T Sueda1, S Fukunaga, Y Matsuura
1Department of Surgery, Hiroshima University, School of Medicine, Japan.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|October 1, 1993
Summary
Two novel liquid oxygenator designs using perfluorocarbon (PFC) demonstrated effective blood oxygenation and carbon dioxide removal in canine models. These devices show promise for extracorporeal gas exchange, though potential microthrombi formation requires further investigation.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Respiratory Physiology
Background:
- Direct blood oxygenation with perfluorocarbon (PFC) offers an alternative to traditional methods.
- PFCs possess high specific gravity and are biocompatible, facilitating gas exchange.
Purpose of the Study:
- To develop and evaluate two distinct liquid oxygenator designs utilizing direct PFC-blood oxygenation.
- To assess the efficacy of these oxygenators in terms of oxygen transfer and carbon dioxide removal in a canine model.
Main Methods:
- Two oxygenator prototypes were designed: a droplet-type and a disk-type unit.
- Both units employed oxygenated perfluorocarbon for direct blood oxygenation.
- Performance was evaluated in mongrel dogs, measuring oxygenation and CO2 removal rates.
Main Results:
- The droplet-type oxygenator showed high oxygenation efficacy (O2 Transfer Rate = 64 ml/min) and CO2 discharge.
- The disk-type oxygenator demonstrated excellent O2 exchange (O2 Transfer Rate = 52 ml/min) and CO2 removal for 2 hours.
- Pathology revealed microthrombi containing PFC in the lung and liver in the droplet-type system.
Conclusions:
- Both developed liquid oxygenator designs are effective for blood gas exchange in a canine model.
- The droplet-type oxygenator showed high gas transfer rates but potential for microthrombi formation.
- The disk-type oxygenator provided sustained gas exchange over a 2-hour period.