Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

European isolation and confinement study. Confinement and immune function

D A Schmitt1, L Schaffar

  • 1Laboratoire d'Immunologie, Faculté de Médecine, Université Paul Sabatier, Toulouse, France.

Advances in Space Biology and Medicine
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissection of immunosuppressive effects of ultraviolet radiation.

Methods in molecular medicine·2012
Same author

Immune responses in extreme environments.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2001
Same author

Head-down tilt bed rest and immune responses.

Pflugers Archiv : European journal of physiology·2001
Same author

Reversal of ultraviolet radiation-induced immune suppression by recombinant interleukin-12: suppression of cytokine production.

Immunology·2000
Same author

Exposure to ultraviolet radiation causes dendritic cells/macrophages to secrete immune-suppressive IL-12p40 homodimers.

Journal of immunology (Baltimore, Md. : 1950)·2000
Same author

The role of cytokines in UV-induced systemic immune suppression.

Journal of dermatological science·2000
Same journal

Primates in space flight.

Advances in space biology and medicine·2005
Same journal

Gravity effects on life processes in aquatic animals.

Advances in space biology and medicine·2005
Same journal

Responses across the gravity continuum: hypergravity to microgravity.

Advances in space biology and medicine·2005
Same journal

Use of animal models to study skeletal effects of space flight.

Advances in space biology and medicine·2005
Same journal

Development as adaptation: a paradigm for gravitational and space biology.

Advances in space biology and medicine·2005
Same journal

Effect of space flight on circadian rhythms.

Advances in space biology and medicine·2005
See all related articles

Spaceflight alters astronaut physiology, impacting the immune system. Simulation studies suggest confinement may reduce immune activity, but further research is needed to analyze immune parameters.

Area of Science:

  • Space physiology
  • Immunology
  • Human physiology in extreme environments

Background:

  • Spaceflight exposes astronauts to unique stressors like weightlessness, radiation, and confinement.
  • These factors are known to cause physiological changes, including alterations in the immune system.
  • Identifying specific space-related causes of immune changes is challenging due to confounding variables.

Purpose of the Study:

  • To investigate the effects of simulated spaceflight stressors on the human immune system.
  • To differentiate the impact of various space-related factors on immune responses.
  • To assess immune activity under controlled confinement conditions.

Main Methods:

  • Review of existing astronaut observations and analogous Earth-based studies.

Related Experiment Videos

  • Analysis of dedicated simulation studies, such as bed rest and confinement experiments.
  • Examination of immunological parameters, including PHA-reactivity and interleukin-2 production in the ISEMSI experiment.

    • Main Results:

    • Previous studies and long-term confinement experiments indicated a reduction in immune activity.
    • A 28-day confinement experiment (ISEMSI) showed a trend towards immune activation in some subjects.
    • Results suggest a complex and potentially variable immune response to confinement.

    Conclusions:

    • Confinement, a key aspect of spaceflight, may lead to immune alterations.
    • Further comprehensive studies are required to fully understand spaceflight's impact on the immune system.
    • Analyzing a wider range of immunological parameters is crucial for future research.