Related Experiment Videos
Synthesis of the metabolites of clentiazem
H Inoue1, S Nakamura, H Otsuka
1Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
Chemical & Pharmaceutical Bulletin
|January 1, 1994
Abstract:
The metabolites of clentiazem in the urine or bile of rats and dogs were investigated. Fifteen basic, 6 acidic, 2 neutral and 4 conjugated metabolites were isolated. In the present paper, fourteen reference compounds as shown in Charts 1, 2 and 3 were synthesized to identify the structures of the metabolites in procedures fundamentally similar to those employed in the synthesis of the corresponding metabolites of diltiazem.