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2,2'-Disubstituted biphenyls: synthesis and suppressive effect against carbon tetrachloride-induced liver injury
K Kondo1, M Takahashi, H Ohmizu
1Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd., Osaka, Japan.
Chemical & Pharmaceutical Bulletin
|January 1, 1994
Abstract:
2,2'-Disubstituted biphenyl compounds (1-15) were synthesized by using the Ullmann coupling reaction as a key step. The suppressive effect of these compounds against CCl4-induced liver injuries in mice was evaluated. An unsymmetrical biphenyl (14f) exhibited the most potent activity. The structure-activity relationship is discussed.