Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Urea removal during continuous hemodiafiltration

D C Frankenfield1, H N Reynolds, C E Wiles

  • 1Department of Nutrition, RA Cowley Shock Trauma Center, Baltimore, MD 21201.

Critical Care Medicine
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Continuous renal replacement therapy in patients following traumatic injury.

The International journal of artificial organs·2006
Same author

Plasma arginine correlations in trauma and sepsis.

Amino acids·2005
Same author

The relationship between plasma cholesterol, amino acids and acute phase proteins in sepsis.

Amino acids·2004
Same author

Co-variation of plasma sodium, taurine and other amino acid levels in critical illness.

Amino acids·2003
Same author

Distortion-product otoacoustic emissions measured at high frequencies in humans.

The Journal of the Acoustical Society of America·2002
Same author

Injuries of the inferior vena cava.

The Surgical clinics of North America·2002
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Attracting Emergency Medicine Graduates to Surgical Critical Care Training Programs.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Beyond a Snapshot: Tracking Family Prognostic Expectations in the ICU.

Critical care medicine·2026
Same journal

The authors reply.

Critical care medicine·2026
Same journal

Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure: Beware of Potential Confounders.

Critical care medicine·2026
See all related articles

Continuous hemodiafiltration effectively removes urea nitrogen, comparable to native kidneys in critically ill patients. Amino acid intake does not need restriction during this renal replacement therapy.

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Intensive Care

Background:

  • Critically ill patients with sepsis and multiple organ failure often require renal replacement therapy.
  • High protein intake, including amino acids, is crucial for nutritional support in these patients.
  • The impact of continuous hemodiafiltration (CHD) on urea nitrogen removal in septic patients with acute renal failure (ARF) receiving high amino acid intake requires investigation.

Purpose of the Study:

  • To compare urea nitrogen removal in critically ill septic patients with ARF undergoing CHD versus septic patients with normal kidney function.
  • To evaluate the relationship between amino acid intake and urea nitrogen removal in both groups.

Main Methods:

  • Prospective, comparative study in a Level I adult trauma hospital.

Related Experiment Videos

  • Fifteen septic patients with ARF on CHD and 11 septic patients without ARF (control group) were enrolled.
  • Urea nitrogen and creatinine levels, and fluid balance were monitored over 6 days.

    • Main Results:

    • Urea nitrogen removal was similar between the CHD group (28 ± 10 g/day) and the control group (27 ± 9 g/day).
    • Blood urea nitrogen remained stable in the CHD group but increased in the control group.
    • Urea nitrogen removal in the CHD group correlated significantly with effluent volume (r² = .69), not amino acid intake.

    Conclusions:

    • Continuous hemodiafiltration effectively removes urea nitrogen, comparable to functional native kidneys.
    • In ARF patients on CHD with high amino acid intake (> 2 g/kg/day), urea nitrogen removal is primarily dependent on effluent volume.
    • Amino acid intake does not require restriction in ARF patients supported by CHD.