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Related Experiment Videos

Spontaneous neoplasms in control Wistar rats

K M Walsh1, J Poteracki

  • 1Department of Pathology and Experimental Toxicology, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105.

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
|January 1, 1994
PubMed
Summary

This study reviewed neoplastic data from Wistar rats, finding most tumors in endocrine and reproductive systems. Pituitary and mammary tumors were most common, with varying incidence between male and female rats.

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Area of Science:

  • Toxicology and Carcinogenesis
  • Laboratory Animal Science
  • Oncology

Background:

  • Carcinogenicity bioassays are crucial for evaluating chemical safety.
  • Establishing baseline tumor incidence in control animals is essential for interpreting study results.
  • Wistar rats are a widely used model organism in toxicological research.

Purpose of the Study:

  • To characterize the spontaneous neoplastic profile of control Wistar rats.
  • To provide reference data for historical carcinogenicity studies.
  • To identify common tumor types and their distribution in male and female rats.

Main Methods:

  • Retrospective analysis of neoplastic data from 1370 control Wistar rats.
  • Data collected from 10 carcinogenicity bioassays conducted between 1980 and 1990.

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  • Histopathological diagnosis and classification of all identified neoplasms.

    • Main Results:

    • Mean survival at 104 weeks was 58% (males) and 59% (females).
    • 1857 neoplasms diagnosed in 68% of males and 85% of females; 12% of malignant tumors showed metastasis.
    • The endocrine and reproductive systems accounted for 74% of all neoplasms, with pituitary and mammary tumors being most prevalent.

    Conclusions:

    • Spontaneous tumor development in Wistar rats is common, particularly in endocrine and reproductive organs.
    • Significant sex-based differences exist in the incidence of specific neoplasms.
    • This data serves as a vital reference for assessing chemical-induced tumorigenesis in Wistar rats.