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Related Experiment Videos

Intestinal permeability

I Bjarnason1

  • 1Department of Clinical Biochemistry, King's College School of Medicine and Dentistry, London.

Gut
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Assessing intestinal permeability with sugar probes offers a non-invasive method to study conditions like Crohn's disease and NSAID effects. This technique helps understand mucosal barrier function and treatment responses.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pharmacology

Background:

  • Intestinal mucosal barrier integrity is crucial for health.
  • Damage to this barrier can be assessed non-invasively using sugar probes.
  • Previous studies highlight the role of intestinal permeability in various gastrointestinal and systemic diseases.

Purpose of the Study:

  • To evaluate the utility of sugar probes for assessing intestinal permeability.
  • To investigate the relationship between intestinal permeability and conditions such as NSAID administration, coeliac disease, and Crohn's disease.
  • To explore the mechanism underlying the therapeutic benefits of elemental diets in Crohn's disease.

Main Methods:

  • Utilized a standardized five-hour urine collection test with specific sugar probes (lactulose/l-rhamnose).

Related Experiment Videos

  • Assessed intestinal permeability in patients undergoing non-steroid anti-inflammatory drug (NSAID) treatment, with untreated coeliac disease, and enteric infections.
  • Correlated permeability measurements with plasma IgA concentrations, neutrophil chemotactic agents, and enterocyte morphology/metabolism.
  • Monitored changes in permeability during elemental diet treatment for Crohn's disease and during relapse periods.

    • Main Results:

    • Sugar probe tests effectively studied NSAID effects, coeliac disease, and enteric infections.
    • Lactulose/l-rhamnose probes proved satisfactory for assessing intestinal permeability.
    • Increased permeability correlated with plasma IgA in nephropathy and passage of neutrophil chemotactic agents.
    • NSAID-induced permeability changes may stem from mitochondrial damage, facilitating bacterial chemoattractant permeation.
    • Untreated Crohn's disease patients exhibited abnormally high permeability, which decreased with elemental diet treatment.
    • Relapse in Crohn's disease correlated with the inability to maintain low intestinal permeability.

    Conclusions:

    • Non-invasive sugar probe testing is a valuable tool for assessing intestinal mucosal barrier function.
    • NSAID-induced enterocyte damage and subsequent bacterial chemoattractant permeation may contribute to inflammation.
    • Elemental enteral nutrition appears beneficial in Crohn's disease by reducing intestinal permeability.
    • Maintaining low intestinal permeability is crucial for sustained remission in Crohn's disease.