Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Motion perception and Alzheimer's disease

G C Gilmore1, H E Wenk, L A Naylor

  • 1Department of Psychology, Case Western Reserve University, Cleveland, OH 44106-7123.

Journal of Gerontology
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

When are nonwords easy to see?

Memory & cognition·2011
Same author

Frequency of behavioral symptoms characterizes agitation in Alzheimer's disease.

International journal of geriatric psychiatry·2001
Same author

On the use of surrogate respondents for controls in a case-control study of Alzheimer's disease.

Journal of the American Geriatrics Society·2001
Same author

Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study.

JAMA·2000
Same author

Determinants of attrition in a natural history study of Alzheimer disease.

Alzheimer disease and associated disorders·1999
Same journal

Shakespeare's attitude towards old age.

Journal of gerontology·2010
Same journal

Involution of tissues in fetal life; a review.

Journal of gerontology·2010
Same journal

Attitudes toward aging and the aged; primitive societies.

Journal of gerontology·2010
Same journal

Budgeting for social security.

Journal of gerontology·2010
Same journal

The Hodson Community Center; an experiment in preservation of personality.

Journal of gerontology·2010
Same journal

Prolongation of life with prevention of leukemia by thymectomy in mice.

Journal of gerontology·2010
See all related articles

Alzheimer disease (AD) patients show impaired motion sensitivity, impacting visual processing. This visual deficit correlates with dementia severity, suggesting a link to the magnocellular pathway disruption.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Gerontology

Background:

  • Alzheimer disease (AD) is a neurodegenerative disorder impacting cognitive function.
  • Neuroanatomical evidence suggests AD may disrupt visual processing pathways.
  • The magnocellular (M) pathway is crucial for motion detection.

Purpose of the Study:

  • To investigate motion sensitivity in individuals with probable AD.
  • To explore the relationship between visual processing deficits and dementia severity.
  • To examine if AD impacts the magnocellular pathway.

Main Methods:

  • Correlated motion paradigm used to assess motion sensitivity.
  • 15 probable AD patients and 15 healthy elderly adults participated.
  • Contrast sensitivity and Mini-Mental State Exam (MMSE) were measured.

Related Experiment Videos

Main Results:

  • AD patients had significantly higher thresholds for detecting motion direction.
  • Motion sensitivity correlated with contrast sensitivity in the AD group.
  • Dementia severity (MMSE) was significantly related to motion sensitivity.

Conclusions:

  • AD disrupts visual signals, potentially in area 17, affecting motion perception.
  • Visual processing deficits in AD are linked to dementia progression.
  • Findings support the hypothesis of M pathway deficits in Alzheimer disease.