Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Intractable bacterial infection--review]

K Matsumoto1, T Nagatake, K Oishi

  • 1Department of Internal Medicine, Nagasaki University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-beta 1 and glucocorticoids.

The Journal of biological chemistry·1992
Same author

Recombinant variants of tissue-type plasminogen activator containing amino acid substitutions in the finger domain.

Thrombosis and haemostasis·1992
Same author

Rapid and marked induction of hepatocyte growth factor during liver regeneration after ischemic or crush injury.

Hepatology (Baltimore, Md.)·1992
Same author

[Clinical manifestation and prognosis of respiratory syncytial virus infection in infants].

Arerugi = [Allergy]·1992
Same author

Sensitive period for the induction of endoreduplication by rotenone in cultured Chinese hamster cells.

Chromosoma·1992
Same author

Ki-67 antibody labeling index in colorectal carcinoma.

Journal of clinical gastroenterology·1992
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Intractable bacterial infections stem from compromised host defenses. Low-dose erythromycin effectively treats diffuse panbronchiolitis (DPB) by addressing bacterial factors and neutrophil damage.

Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Microbiology

Context:

  • Intractable bacterial infections arise from compromised host defense mechanisms.
  • Diffuse panbronchiolitis (DPB) involves Pseudomonas aeruginosa and neutrophil accumulation in airways.

Purpose:

  • To investigate the mechanisms of intractable bacterial infections, focusing on DPB.
  • To evaluate the efficacy of low-dose erythromycin therapy in DPB.
  • To explore the role of bacterial factors and interleukin-8 (IL-8) in treatment response.

Summary:

  • Compromised host defenses (systemic, local, iatrogenic) contribute to intractable bacterial infections.
  • Destroyed neutrophils in airways are implicated in DPB pathogenesis.
  • Low-dose erythromycin is effective for intractable DPB, with evidence suggesting specific mechanisms and impact on IL-8 levels in bronchoalveolar lavage fluid (BALF).

Related Experiment Videos

Impact:

  • Provides insights into DPB treatment mechanisms, particularly low-dose erythromycin.
  • Highlights the role of bacterial factors and neutrophil degradation in persistent infections.
  • Suggests potential therapeutic targets for managing intractable airway infections.