[The intractable bacterial infection in the pediatric field]

In recent years, medical treatment of neonates, especially premature infants, has made a remarkable progress, but the rate of neonatal mortality from bacterial infection has not decreased. Our early diagnosis and treatment of neonatal bacterial infection was discussed as below, 1) The rate of onset of neonatal sepsis was higher in neonates under 1500 gr birth weight, and a trend for increase of E. cloacae, which is the main causative organism of sepsis in recent years, was recognized. 2) The intestinal tract, skin, and some kinds of catheters were suggested as the main root of sepsis. Therefore the following three points, namely, selection of antibiotics which has less influence in the intestinal flora, early treatment of skin infection, and regular culture of surveillance are highly important in early diagnosis and treatment and prevention of infections.