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Possible application of the laser in immunobiology
1Department of Microbiology, School of Medicine, Keio University, Tokyo, Japan.
The Keio Journal of Medicine
|December 1, 1993
Summary
Low reactive-level laser therapy (LLLT) shows potential in modulating immune responses. Research indicates LLLT can enhance immune cell activity and may offer therapeutic benefits for autoimmune diseases.
Area of Science:
- Immunology
- Photobiology
- Laser Therapy
Background:
- The human immune system distinguishes self from non-self using mechanisms like Major Histocompatibility Complex (MHC) antigens.
- Dysregulation of the immune system can lead to autoimmune diseases.
- Low reactive-level laser therapy (LLLT) is being investigated for its effects on immune cells.
Purpose of the Study:
- To explore the immunomodulatory effects of visible light and infrared LLLT.
- To assess LLLT's potential in treating immune system disorders and enhancing immune responses.
Main Methods:
- Review of experimental and clinical data on LLLT's impact on immune cells.
- Investigation of photobiological activation and photodynamic therapy (PDT) principles.
Main Results:
- Infrared LLLT demonstrated increased phagocytic and chemotactic activity of human leukocytes in vitro.
- LLLT can directly and selectively influence the autoimmune system, potentially restoring immunocompetence.
- Photobiological cell-specific destruction is achievable with photosensitized cells and specific laser wavelengths (e.g., PDT for cancers).
Conclusions:
- LLLT exhibits a promising role in immunobiological therapy for immune system diseases.
- LLLT may activate and boost normal immune responses against foreign bodies.
- Further research is warranted to fully elucidate LLLT's therapeutic potential in immunology.
