Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Re-evaluation of pyrazinamide]

A Kajiki1

  • 1National Ohmuta Hospital, Fukuoka, Japan.

Kekkaku : [Tuberculosis]
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Pyrazinamide (PZA) showed a higher culture negative conversion rate in a short-course tuberculosis chemotherapy trial. Despite concerns about adverse reactions, PZA use is low among Japanese specialists, necessitating further research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary Mycobacterium avium complex infection associated with the IVS8-T5 allele of the CFTR gene.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2007
Same author

[Pulmonary Mycobacterium Kansasii infection in the southern area of Fukuoka prefecture].

Kekkaku : [Tuberculosis]·2001
Same author

[Comparison of chest CT findings between suspected and definite cases of primary pulmonary M. avium complex infection].

Kekkaku : [Tuberculosis]·2000
Same author

[A study of sialylated carbohydrate antigen in patients with benign bronchopulmonary disease].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society·1999
Same author

[Diagnostic usefulness of the tuberculin reaction by PPD-B in Mycobacterium avium complex disease].

Kekkaku : [Tuberculosis]·1998
Same author

[The distribution and the characteristics in computed tomography (CT) of the lungs in primary Mycobacterium avium complex (MAC) infection].

Kekkaku : [Tuberculosis]·1997

Area of Science:

  • Medical Research
  • Pharmacology
  • Infectious Diseases

Background:

  • Pyrazinamide (PZA) is a critical drug in short-course anti-tuberculosis chemotherapy.
  • Its efficacy and safety profile require ongoing evaluation within clinical practice.

Purpose of the Study:

  • To re-evaluate the role of Pyrazinamide (PZA) in short-course anti-tuberculosis chemotherapy.
  • To assess Japanese tuberculosis specialists' perceptions and usage of PZA.

Main Methods:

  • A clinical trial of short-course chemotherapy including PZA was conducted.
  • A questionnaire survey was administered to Japanese tuberculosis specialists regarding PZA estimation.

Main Results:

  • The PZA group exhibited a higher rate of negative culture conversion at two months compared to the control group.

Related Experiment Videos

  • While overall adverse reactions were higher in the PZA group, liver dysfunction incidence was lower.
  • Only about 20% of specialists utilize PZA for newly diagnosed tuberculosis patients due to perceived adverse effects, ineffectiveness, or availability of alternatives.

    • Conclusions:

    • Pyrazinamide (PZA) may offer benefits in tuberculosis treatment, indicated by improved negative conversion rates.
    • Specialist reluctance to use PZA highlights a gap between clinical trial data and practice.
    • A rigorous, nationwide cooperative study is essential to definitively establish the utility of PZA in tuberculosis chemotherapy.