Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interferon system defects in malignant T-cells

M Heyman1, D Grandér, K Bröndum-Nielsen

  • 1Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.

Leukemia
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seroprevalence of hepatitis A virus antibody in a population aged 0-30 years in Shanghai, China: implications for hepatitis A immunization.

Epidemiology and infection·2012
Same author

Analysis of the aetiology of diarrhoea in outpatients in 2007, Henan province, China.

Epidemiology and infection·2012
Same author

Construction of a recombinant plasmid harbouring the glyceraldenyde-3-phosphate dehydrogenase gene of periodic Brugia malayi and observation on DNA immunity.

Indian journal of medical microbiology·2012
Same author

A common genetic variant of 5p15.33 is associated with risk for prostate cancer in the Chinese population.

Genetics and molecular research : GMR·2012
Same author

Recent transmission of W-Beijing family Mycobacterium tuberculosis in rural eastern China.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2012
Same author

Characterization of the neuropeptide Y system in the frog Silurana tropicalis (Pipidae): three peptides and six receptor subtypes.

General and comparative endocrinology·2012
Same journal

Linperlisib enhances MUC1-Tn CAR T cell efficacy by inhibiting EGR1/DUSP2 axis to prevent CAR T cell exhaustion.

Leukemia·2026
Same journal

CD7 chimeric antigen receptor T cells in patients with relapsed or refractory CD7-positive acute myeloid leukemia.

Leukemia·2026
Same journal

Single-cell architecture of purinergic signaling in human cord blood hematopoietic stem and progenitor cells.

Leukemia·2026
Same journal

Feasibility and safety of rapid glofitamab ramp-up.

Leukemia·2026
Same journal

Single-cell DNA methylation analysis uncovers epigenetic pathways in the transformation of MDS to AML.

Leukemia·2026
Same journal

PD-L2 is associated with lineage-related transcriptional programs distinct from PD-L1 in primary mediastinal large B-cell lymphoma.

Leukemia·2026
See all related articles

Chromosome 9p deletions in T-cell lines frequently involve alpha- and beta-interferon (IFN) genes. Loss of these IFN genes did not correlate with IFN system function, suggesting complex regulation in cancers like ALL.

Area of Science:

  • Genetics
  • Immunology
  • Oncology

Background:

  • Chromosome 9p21-22 deletions are common in acute lymphocytic leukemia (ALL), melanoma, and glioma.
  • These deletions often encompass the alpha- and beta-interferon (IFN) genes, crucial components of the innate immune system.

Purpose of the Study:

  • To investigate the frequency of alpha- and beta-IFN gene deletions in T-cell lines.
  • To correlate IFN gene status with other IFN system parameters, including production, receptor expression, and cellular response.

Main Methods:

  • Analysis of 17 T-cell lines for alpha- and beta-IFN gene deletions using cytogenetic and molecular methods.
  • Assessment of IFN production, IFN-alpha receptor number, 2',5' oligoadenylate synthetase induction, and growth inhibition assays.
  • Evaluation of loss of heterozygosity (LOH) for IFN gene markers.

Related Experiment Videos

Main Results:

  • Alpha- and beta-IFN gene deletions were found in 7 out of 17 T-cell lines, with two showing homozygous deletions.
  • An increased rate of homozygosity for IFN gene markers (40%) suggested potential LOH in other cell lines.
  • No significant correlation was observed between IFN gene loss and IFN production capacity or cellular sensitivity to IFN.
  • Deficiencies in IFN production or response were observed even in cell lines with normal IFN gene dosage.

Conclusions:

  • IFN gene deletions are frequent in T-cell lines relevant to cancers like ALL.
  • The IFN system's function appears to be regulated independently of direct IFN gene dosage, suggesting complex regulatory mechanisms.
  • Further research is needed to understand the interplay between IFN genes and the broader IFN system in cancer development and progression.