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Related Experiment Videos

Neonatal tumours: a thirty-year population-based study

S E Parkes1, K R Muir, L Southern

  • 1West Midlands Regional Children's Tumour Research Group, Children's Hospital, Birmingham, United Kingdom.

Medical and Pediatric Oncology
|January 1, 1994
PubMed
Summary

Neonatal tumors (birth-3 months) incidence and outcomes were studied over 30 years. Despite varied diagnoses like leukemia and teratoma, 55% survived one year, suggesting potential for better prognoses with specialized care.

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Area of Science:

  • Pediatric Oncology
  • Epidemiology
  • Neonatal Medicine

Background:

  • Uncertainty surrounds neonatal tumor incidence and outcomes.
  • Existing reports often stem from single-center, selected experiences.
  • Definitions and histological predictors for neonatal tumors lack clarity.

Purpose of the Study:

  • To document the incidence, clinical features, and outcomes of neonatal tumors.
  • To analyze a 30-year population-based dataset (1960-1989).
  • To inform individualized treatment strategies and highlight the need for specialized centers.

Main Methods:

  • Population-based pediatric cancer register analysis.
  • 30-year study period (1960-1989).
  • Case note and pathology review of 170 identified neonatal tumor cases (birth-3 months).

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Main Results:

  • Overall incidence of neonatal tumors increased over the study period.
  • Mature teratoma was the most common diagnosis (29%); 58% diagnosed within the first month.
  • Leukemias (21 cases) and CNS tumors (14 cases) were identified among 135 solid tumors.
  • 16% had relevant family history; 15% had congenital abnormalities.
  • Overall 1-year survival was 55%, with leukemia showing the poorest prognosis.

Conclusions:

  • Neonatal tumor incidence is increasing, with significant proportions diagnosed early.
  • While leukemia has a poor prognosis, many neonatal tumors may have a better outlook than previously thought.
  • Individualized treatment and assessment at dedicated pediatric oncology centers are crucial for improving outcomes.