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[Cutaneous microcirculation in systemic sclerosis. Morpho-functional research using capillaroscopy and laser-Doppler]

G Dragagna1, A Saponaro, F Valentini

  • 1Dipartimento Scienze Cardiovascolari e Respiratorie, Università degli Studi di Roma La Sapienza.

Minerva Cardioangiologica
|November 1, 1993
PubMed
Summary

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Systemic sclerosis patients exhibit significant microcirculatory damage compared to primary Raynaud disease. Early diagnosis of secondary Raynaud phenomenon is crucial for predicting systemic sclerosis progression and organ damage.

Area of Science:

  • Rheumatology
  • Dermatology
  • Vascular Biology

Context:

  • Raynaud phenomenon is a condition affecting small blood vessels, often in the fingers and toes.
  • Systemic sclerosis is an autoimmune disease characterized by hardening and tightening of the skin and connective tissues.
  • Microcirculatory alterations are a key feature in Raynaud disease and systemic sclerosis.

Purpose:

  • To compare the cutaneous microvasculature in patients with systemic sclerosis, primary Raynaud disease, and healthy subjects.
  • To evaluate the morphological and functional aspects of small vessels using videocapillaroscopy and laser-Doppler fluxmetry.
  • To investigate the role of microangiopathy in the development of organ damage in advanced systemic sclerosis.

Summary:

  • Patients with systemic sclerosis showed reduced resting blood flow and deranged small vessel morphology compared to primary Raynaud disease and healthy controls.

Related Experiment Videos

  • An ischemic test revealed "no responders" (44%) and "responders" (56%) in the systemic sclerosis group, with the latter showing prolonged reactive hyperemia.
  • Videocapillaroscopy revealed a significantly more severe capillaroscopic pattern in systemic sclerosis patients.

    • Impact:

    • Microangiopathy, including thromboischemic and inflammatory aspects, is critical in driving organ damage in advanced systemic sclerosis.
    • Distinguishing between primary and secondary Raynaud phenomenon through clinical and instrumental tests is vital.
    • Early differential diagnosis holds significant prognostic value for identifying patients at risk of developing systemic sclerosis.