Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Atrial natriuretic factor: a "physiological diuretic"]

A Haris1, J Radó

  • 1Uzsoki Utcai Kórház, III. Belgyógyászati Osztály, Budapest.

Orvosi Hetilap
|February 13, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kidney health for all: caring for people, protecting the planet.

Hong Kong medical journal = Xianggang yi xue za zhi·2026
Same author

Are your kidneys OK? Detect early to protect kidney health.

Hong Kong medical journal = Xianggang yi xue za zhi·2025
Same author

Mind the gap in kidney care: translating what we know into what we do.

Hong Kong medical journal = Xianggang yi xue za zhi·2024
Same author

Incidence and clinical predictors of infections in patients treated with severe systemic ANCA-associated vasculitis.

Physiology international·2021
Same author

Targeted energy transfer and modal energy redistribution in automotive drivetrains.

Nonlinear dynamics·2020
Same author

Care for chronic renal patients - Role of multidisciplinary education.

Physiology international·2018

Atrial natriuretic peptide (ANF), a "physiological diuretic," is crucial for maintaining volume homeostasis. While ANF has significant cardiovascular and renal effects, its therapeutic use in volume-retaining disorders requires further clinical investigation.

Area of Science:

  • Endocrinology and Physiology
  • Cardiovascular and Renal Systems

Context:

  • The atrial natriuretic peptide (ANF) is a peptide hormone synthesized in atrial granules and extra-atrial organs.
  • ANF belongs to a peptide family including brain, C-type natriuretic peptides, and urodilatin.
  • Its release is primarily stimulated by atrial wall distension, with other regulatory mechanisms also involved.

Purpose:

  • To elucidate the role of atrial natriuretic peptide (ANF) in maintaining volume homeostasis.
  • To detail the cardiovascular, renal, and endocrine regulatory properties of ANF.
  • To explore the potential therapeutic applications of ANF in volume-retaining disorders.

Summary:

  • ANF exerts vasodilatory effects, lowers blood pressure, and increases glomerular filtration rate and renal blood flow.

Related Experiment Videos

  • It inhibits sodium and water reabsorption in renal tubules, promoting natriuresis and diuresis.
  • ANF acts as a counterregulatory hormone to the renin-angiotensin-aldosterone system and interacts complexly with vasopressin.

    • Impact:

    • Elevated serum ANF levels are observed in edematous disorders, though tubular resistance can occur.
    • ANF's therapeutic potential as a "physiological diuretic" in volume-retaining conditions is proposed but requires further clinical validation.
    • Understanding ANF's mechanisms is vital for potential future treatments of fluid balance disorders.