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Mediastinal histoplasmosis with esophageal abscess. Two case reports
Gastroenterology
|January 1, 1976
Summary
Histoplasma capsulatum can infect mediastinal nodes, causing esophageal erosion and dysphagia. Prompt diagnosis and amphotericin B treatment led to positive outcomes in two patients.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Gastroenterology
Background:
- Histoplasma capsulatum is an endemic fungus causing systemic infections.
- Mediastinal lymphadenopathy is a common manifestation of histoplasmosis.
- Esophageal involvement is a rare but serious complication.
Observation:
- Two patients presented with mediastinal lymph node histoplasmosis.
- Nodes eroded into the esophagus, causing significant dysphagia.
- Fungal serology aided diagnosis in one case.
Findings:
- Both patients received amphotericin B treatment with good clinical response.
- One patient developed a traction diverticulum post-treatment.
- Histoplasmosis can lead to esophageal complications requiring antifungal therapy.
Implications:
- Highlights the importance of considering fungal infections in esophageal pathology.
- Demonstrates the efficacy of amphotericin B in severe histoplasmosis.
- Suggests potential long-term esophageal sequelae after successful treatment.
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