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Synthesis of phosphorothioate-methylphosphonate oligonucleotide co-polymers
L Zhou1, A M Morocho, B C Chen
1Pharmacology Department, Georgetown University Medical Center, Washington, DC 20007.
Nucleic Acids Research
|February 11, 1994
Abstract:
We describe the synthesis and characterization of novel phosphorothioate-methylphosphonate backbone-modified oligodeoxynucleotide co-polymers. These may have potential use as antisense constructs.