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Related Experiment Videos

[Primary anorectal malignant melanomas. 2 cases]

I Sielezneff1, R Boutboul, P Thomas

  • 1Service de Chirurgie viscérale, Centre Hospitalier Général, Salon-de-Provence.

Presse Medicale (Paris, France : 1983)
|December 18, 1993
PubMed
Summary
This summary is machine-generated.

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Primary anorectal melanoma is a rare and aggressive cancer. Early diagnosis and radical surgery offer the best chance for survival, while other treatments manage advanced stages.

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Primary anorectal melanoma is a rare malignancy with a poor prognosis, typically presenting with a 5-year survival rate of 7-12%.
  • Diagnosis can be challenging due to lack of pigmentation in a significant percentage of cases (16-53%) and histological ambiguity in up to 30%.

Observation:

  • Two cases of primary anorectal melanoma are presented.
  • Diagnostic difficulties were noted, particularly in non-pigmented lesions.
  • Histological examination posed diagnostic challenges in a subset of cases.

Findings:

  • Immunohistochemical markers (vimentin, PS100, HMB45) aid in post-excision diagnosis.
  • Radical abdominal perineal resection can be curative for lesions <2 mm wide.
  • For advanced lesions (Breslow stage IV-V), local excision offers palliation, radiation is palliative for extensive tumors, and combined chemotherapy (fotemustine, dacarbazine) may be used for metastatic disease.

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Implications:

  • Emphasizes the importance of immunohistochemistry in diagnosing amelanotic anorectal melanoma.
  • Highlights radical surgery as crucial for long-term survival in early-stage disease.
  • Suggests multimodal treatment approaches for advanced or metastatic anorectal melanoma.