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Updated: Aug 17, 2026

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation
Published on: October 1, 2012
[Immune status in patients with bone and joint tuberculosis and effect of HLA genotype]
Abstract:
The study included 41 patients (Uzbeks by nationality) with tuberculosis of the bones and joints. Of them 19 had localized tuberculosis and 22 disseminated process. The condition of T lymphocytes, B-lymphocytes and specific immunity were investigated by standard immunological methods. Typing by antigens HLA-DR was made with the help of standard microlymphocytotoxic test. It was established that patients with tuberculosis of the bones and joints have worse qualitative and quantitative characteristics of T lymphocytes, reduced number of B-lymphocytes, high specific response of lymphocytes to tuberculin compared to healthy subjects. Such patients have low B-cell level when they are free of antigen HLA-DR4. Carriers of HLA-DR2 antigen exhibit inhibited specific cellular immunity compared to those without this antigen.
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