[Lipid metabolism and atherogenesis in tuberculosis in experimental animals]

As shown in experiments on intact rabbits (60), rabbits with experimental tuberculosis (20), experimental atherosclerosis (30) and atherosclerosis concurrent with tuberculosis (35), disorders in lipid metabolism in pulmonary and combined affections follow the same pattern. This presents with atherogenic dysalpha- and dyslipoproteinemia, high levels of free cholesterol in the lipid phase of atherogenic lipoproteins, increased red cell ratio cholesterol/phospholipids, red cell enrichment with not easily oxidized phospholipids, activation of free radical oxidation of plasma and red cell lipids. Tuberculosis promotes lipoidosis formation making worse its development.