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Antimeasles antibodies in children submitted to different vaccination schedules
S A de Oliveira1, A Homma, L Camillo-Coura
1Disciplina de Doenças Infecciosas e Parasitárias, Universidade Federal Fluminense, Niterói, RJ, Brasil.
Insights
Vaccinating children against measles before age one resulted in lower antibody levels compared to later vaccination. Early measles vaccination impacts antibody development and immune response effectiveness.
Area of Science:
- Immunology
- Pediatrics
- Vaccinology
Background:
- Measles vaccination is crucial for public health.
- Understanding the impact of vaccination timing on immune response is essential.
Purpose of the Study:
- To investigate the measles antibody behavior across different vaccination schedules.
- To determine the influence of age at vaccination on measles antibody titers.
Main Methods:
- 684 children were divided into four groups: early vaccination, one-year vaccination, combined schedules, and unvaccinated controls.
- Antibody titers were measured using hemagglutination inhibition (HI) assays.
- Statistical analysis compared antibody levels across groups.
Main Results:
- Children vaccinated before one year (Group A) showed lower measles antibody rates, with 25.9% lacking antibodies.
- Children vaccinated at one year (Group B) and combined schedules (Group C) demonstrated higher antibody presence.
- Geometric mean HI antibody titers were lowest in the early vaccination group (Group A).
Conclusions:
- The age at which measles vaccination is administered significantly influences antibody development.
- Vaccination at one year of age appears more effective in establishing measles immunity than vaccination before one year.
Abstract:
In order to study the measles antibody behavior of three vaccination schedules, 684 children were divided into 4 Groups: Group A (341 vaccinated children under the age of one); Group B (101 children at the age of one); Group C (74 children under the age of one and one at the age of one); Group D (163 unvaccinated children with a history of measles in the past-Group control). Children of Group A presented lower rates and 25.9% of the age group under two did not show any measles antibodies. In Group B, all the children presented antibodies. In Group C only 4.0% did not. In all age groups, the geometric mean HI antibody titers of Group A were lower than the values found in the other groups. The age at vaccination was the factor of greater influence on the results of this study.