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Related Experiment Videos

[Are maltose infusions suitable for infusion therapy]

H Fŏrster, I Hoos, S Boecker

    Infusionstherapie Und Klinische Ernahrung
    |December 1, 1975
    PubMed
    Summary

    Maltose is not suitable for intravenous therapy due to limited human metabolic capacity. High urinary losses of maltose and glucose occur, especially at higher infusion rates, making it inefficient for parenteral nutrition.

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    Area of Science:

    • Metabolic studies
    • Clinical investigation
    • Nutritional science

    Context:

    • Parenteral nutrition requires safe and effective carbohydrate sources.
    • Maltose is a disaccharide that could potentially be used in intravenous feeding.
    • Understanding maltose metabolism is crucial for its clinical application.

    Purpose:

    • To investigate the suitability of maltose for parenteral nutrition in healthy volunteers.
    • To determine the metabolic capacity and tolerance of intravenous maltose infusions.
    • To assess urinary losses and blood concentration changes associated with maltose administration.

    Summary:

    • Healthy volunteers received intravenous maltose at varying doses (0.125, 0.25, 0.5 g/kg BW/h).
    • Maltose infusions were tolerated, but a steady state in blood concentration was only achieved at the lowest dose (0.125 g/kg BW/h).
    • Limited metabolic capacity led to significant urinary losses (20-30%) of maltose and glucose, particularly at higher rates.

    Impact:

    • The study concludes that maltose is not appropriate for intravenous therapy due to inefficient metabolism.
    • High renal losses result in significant wastage of the administered carbohydrate.
    • Findings highlight the importance of considering metabolic limitations in the selection of parenteral nutrition substrates.

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