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Related Experiment Videos

The new macrolides. Azithromycin and clarithromycin

M S Kanatani1, B J Guglielmo

  • 1Division of Clinical Pharmacy, University of California, School of Pharmacy, San Francisco 94143-0622.

The Western Journal of Medicine
|January 1, 1994
PubMed
Summary

New macrolide antibiotics, clarithromycin and azithromycin, offer less frequent dosing and potential antimicrobial advantages against certain pathogens. While more expensive, their convenience may be beneficial for specific infections.

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Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Microbiology

Background:

  • Clarithromycin and azithromycin represent a new generation of macrolide antibiotics.
  • These agents offer potential advantages in dosing frequency and duration compared to older antibiotics.

Purpose of the Study:

  • To evaluate the antimicrobial spectrum and clinical utility of clarithromycin and azithromycin.
  • To compare the efficacy and convenience of these new macrolides against existing treatments.

Main Methods:

  • In vitro susceptibility testing against various microbial species.
  • Clinical comparison with erythromycin and doxycycline for specific infections.

Main Results:

  • Clarithromycin and azithromycin demonstrated in vitro activity against atypical mycobacteria, toxoplasmal species, and potentially Haemophilus influenzae.

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  • Azithromycin's single-dose regimen is convenient for chlamydial infections compared to doxycycline's 7-day course.
  • These macrolides show advantages over erythromycin for Mycobacterium avium-intracellulare treatment.

    • Conclusions:

    • Clarithromycin and azithromycin possess a favorable antimicrobial profile against select pathogens.
    • Their higher cost is a consideration, but dosing convenience may offset this for certain indications.
    • Further research is required to define the full clinical role of these new macrolides in bacterial infections.