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Related Experiment Videos

Static and dynamic pulmonary compliance during upright immersion

N A Taylor1, J B Morrison

  • 1Department of Biomedical Sciences, University of Wollongong, Australia.

Acta Physiologica Scandinavica
|December 1, 1993
PubMed
Summary

Dynamic pulmonary compliance (Cdyn(1)) decreases during immersion breathing at mouth pressure, suggesting it reflects airway resistance, not lung elasticity. This highlights the importance of breathing gas pressure for accurate dynamic compliance measurements.

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Area of Science:

  • Physiology
  • Respiratory Medicine
  • Pulmonary Function Testing

Background:

  • Lung elastic properties are traditionally measured using static pressure-volume maneuvers.
  • Dynamic methods for assessing lung compliance have yielded comparable results in healthy individuals.
  • However, the validity of dynamic methods in obstructive lung diseases and specific conditions remains debated.

Purpose of the Study:

  • To investigate the impact of immersion on static (Cst(1)) and dynamic (Cdyn(1)) pulmonary compliance.
  • To determine if breathing gas pressure (mouth vs. lung centroid) influences Cdyn(1) measurements during immersion.
  • To clarify the interpretation of Cdyn(1) as an index of lung elasticity versus peripheral airway patency.

Main Methods:

  • Eight subjects underwent measurements of Cst(1) and Cdyn(1) in air (control) and during immersion.

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  • Breathing gas was supplied at mouth pressure during initial immersion.
  • Subsequently, breathing gas was supplied at lung centroid pressure (PLC) during immersion.

    • Main Results:

    • Immersion with breathing at mouth pressure significantly decreased Cdyn(1) (2.94 to 1.61 l kPa-1; P < 0.05), while Cst(1) remained unchanged (3.16 to 4.07 l kPa-1; P > 0.05).
    • Supplying breathing gas at PLC during immersion restored Cdyn(1) to control levels (2.89 l kPa-1; P > 0.05) and maintained stable Cst(1) (3.60 l kPa-1; P > 0.05).
    • A notable difference between Cst(1) and Cdyn(1) suggests flow-resistive properties are incorporated into dynamic compliance measurements.

    Conclusions:

    • Dynamic pulmonary compliance (Cdyn(1)) measurements during immersion are sensitive to breathing gas pressure.
    • Cdyn(1) appears to include flow-resistive components, making it a less reliable indicator of pure lung elasticity under these conditions.
    • Cdyn(1) should be interpreted as an index of peripheral airway patency rather than lung elasticity during immersion with mouth pressure breathing.