Increased ascitic fluid prorenin in the ovarian hyperstimulation syndrome
M E Rosenberg1, J K Mckenzie, I M Mckenzie
1Department of Medicine, University of Minnesota, Minneapolis.
Abstract:
Three patients developed severe ovarian hyperstimulation syndrome (OHS) as a complication of ovarian hyperstimulation for in vitro fertilization. These patients presented with ovarian enlargement, vascular volume depletion, pleural effusions, and exudative ascites. A unique feature of the ascites in OHS was the markedly elevated renin concentration, the majority of which was prorenin. We speculate the renin-angiotensin system (RAS) may play a pathophysiologic role in the localized capillary leak that develops in OHS.
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