Coronary artery disease risk factors from a genetic and developmental perspective

The genetic nature of obesity, hypertension, non-insulin-dependent diabetes, and low-density lipoprotein levels was reviewed. Obesity, hypertension, and diabetes are evolving conditions that are associated with early changes in lipid and carbohydrate metabolism. An appreciation of the genetic nature of these conditions should be useful in devising screening strategies for family members who are at risk for coronary artery disease because of their family history.