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Differential modulation of brain benzodiazepine receptor subtypes by ricinelaidic acid in vitro
1Research Institute of Biological Psychiatry, St Hans Hospital, Roskilde, Denmark.
Biochemical Pharmacology
|February 11, 1994
Abstract:
The C-18 hydroxy fatty acids ricinelaidic acid and ricinoleic acid diminish the oleic acid-stimulated agonist benzodiazepine binding in the rat brain in vitro. The oleic acid-induced enhancement of [3H]diazepam binding was completely abolished in membranes from the cerebellum, but only partially decreased in membranes from the hippocampus, cortex and the whole brain from 7-day-old rat pups. Related hydroxy fatty acids as well as hydroxy fatty acid esters had no effect on the oleic acid-stimulated diazepam receptor binding.