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Oncorna-like viruses in baboon prostate tissue

S S Kalter, S A Shain, G C Smith

    Journal of the National Cancer Institute
    |November 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Oncorna-like virus particles were found in baboon prostate tissue after chemical carcinogen exposure. No link was found between the carcinogen and virus development, with no signs of neoplasia observed.

    Area of Science:

    • Veterinary Pathology
    • Oncology
    • Virology

    Background:

    • Chemical carcinogens are investigated for their role in inducing prostate abnormalities.
    • Viral oncogenesis is a known factor in some animal cancers.
    • Long-term effects of chemical exposure in non-human primates are studied.

    Purpose of the Study:

    • To investigate the presence and nature of virus particles in baboon prostate tissue following chemical carcinogen inoculation.
    • To determine any potential association between chemical carcinogen exposure and the development of oncornavirus-like particles.
    • To assess the neoplastic status of prostate tissue in inoculated baboons.

    Main Methods:

    • Inoculation of baboons with a chemical carcinogen.
    • Long-term observation (3 years) post-inoculation.

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  • Biopsy of prostate tissue.
  • Electron microscopic examination of tissue samples.

    • Main Results:

    • Oncorna-like virus particles were detected in the prostate tissue of 2 out of 11 inoculated baboons.
    • No evidence of neoplasia (cancer) was found in the biopsy specimens.
    • Electron microscopy suggested classification of the observed virus as a B-type oncornavirus.
    • No correlation was established between the chemical carcinogen and the appearance of virus particles.

    Conclusions:

    • The study did not find evidence linking chemical carcinogen exposure to the development of oncornavirus-like particles in baboon prostate tissue.
    • The observed virus particles were characterized as B-type oncornavirus based on electron microscopic findings.
    • Further research may be needed to understand the origin and significance of these viral particles in the absence of neoplastic changes.