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Related Experiment Videos

Pulmonary compliance changes after experimental head injury

M W Brueggemann, R G Loudon, R L McLaurin

    The Journal of Trauma
    |January 1, 1976
    PubMed
    Summary

    Head trauma in monkeys did not alter lung compliance until immediately before death. This suggests pulmonary mechanical characteristics may remain stable until the critical point of demise following severe head injury.

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    Area of Science:

    • Pulmonary Medicine
    • Trauma Research
    • Experimental Physiology

    Background:

    • Previous studies indicated reduced static lung compliance in animals post-head injury.
    • The clinical relevance of these findings in humans remained unclear.

    Purpose of the Study:

    • To investigate pulmonary dynamic compliance changes after severe head trauma in a primate model.
    • To correlate these changes with clinical observations in humans.

    Main Methods:

    • Continuous pulmonary dynamic compliance measurements using clinically applicable methods.
    • Severe head trauma induced in 18 monkeys, followed by a 2-hour observation period.

    Main Results:

    • Pulmonary compliance significantly decreased only in animals that died during the observation period, specifically at the time of death.

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  • Monkeys that survived the 2-hour observation and were subsequently euthanized showed no decrease in compliance.

    • Conclusions:

    • Lung mechanical characteristics following head trauma in experimental animals can be assessed using clinical methods.
    • Pulmonary compliance may remain unchanged until immediately prior to death after severe head trauma.