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Do diets enriched with oil prevent multiple organ failure in mice?
C J Gielen1, A B van As, R J Goris
1Department of General Surgery, University Hospital Nijmegen, The Netherlands.
The European Journal of Surgery = Acta Chirurgica
|November 1, 1993
Summary
Fish oil-supplemented diets did not prevent multiple organ failure in mice. Gut decontamination also failed to alter outcomes, indicating limited dietary impact on this condition.
Area of Science:
- Experimental pathology
- Nutritional science
- Immunology
Background:
- Multiple organ failure (MOF) is a critical condition with high mortality.
- Dietary interventions are explored to mitigate MOF, with a focus on fat supplementation.
- Tumor necrosis factor-alpha (TNF-alpha) is a key inflammatory mediator in MOF.
Purpose of the Study:
- To investigate the efficacy of diets supplemented with fish oil or palm oil in an experimental model of multiple organ failure.
- To assess the impact of gut decontamination on MOF outcomes.
- To measure plasma concentrations of TNF-alpha in response to dietary interventions.
Main Methods:
- Two randomized laboratory studies involving 177 female Swiss mice.
- Mice received diets supplemented with palm oil or fish oil for 8-12 weeks prior to inducing MOF via zymosan injection.
- Experiment II included gut decontamination with streptomycin.
Main Results:
- Fish oil supplementation did not improve survival rates in Experiment I.
- In Experiment II, liver weights were lower and kidney weights higher in the fish oil group compared to controls.
- Plasma TNF-alpha levels were not significantly affected by dietary interventions, and gut decontamination showed no impact.
Conclusions:
- Dietary supplementation with fish oil does not prevent multiple organ failure in this experimental model.
- Fish oil did not reduce plasma TNF-alpha concentrations.
- Gut decontamination did not alter the outcomes of MOF in the studied groups.