Related Experiment Videos
Angiotensin responsiveness in hyperfiltering and nonhyperfiltering diabetic rats
B M Wilkes1, P F Mento, M A Vernace
1Department of Medicine, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030.
Journal of the American Society of Nephrology : JASN
|December 1, 1993
Summary
In diabetic rats, angiotensin II normalized hyperfiltration, suggesting localized kidney abnormalities. This study investigates renal responses to angiotensin II in diabetes.
Area of Science:
- Nephrology
- Endocrinology
- Pharmacology
Background:
- Diabetes mellitus is associated with altered renal hemodynamics.
- Hyperglycemia can lead to changes in glomerular filtration rate (GFR).
Purpose of the Study:
- To investigate the renal and systemic responses to angiotensin II in diabetic rats.
- To determine if angiotensin II affects GFR differently in hyperfiltering versus non-hyperfiltering diabetic rats.
Main Methods:
- Streptozotocin-induced diabetes in rats.
- Measurement of GFR, mean arterial pressure, plasma glucose, and urine volume at various time points.
- Intravenous infusion of angiotensin II.
Main Results:
- Hyperfiltration (elevated GFR) was observed in diabetic rats at 1 week but varied at other time points.
- Angiotensin II normalized GFR in hyperfiltering diabetic rats but had no effect on normal or non-hyperfiltering diabetic rats.
- Blood pressure responses to angiotensin II were similar in hyperfiltering and non-hyperfiltering diabetic rats.
Conclusions:
- Angiotensin II exhibits differential effects on GFR in diabetic rats, normalizing it in hyperfiltering individuals.
- The distinct renal response to angiotensin II suggests a localized abnormality in kidney angiotensin responsiveness in diabetes.
- These findings have implications for understanding diabetic nephropathy and potential therapeutic targets.