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Updated: Aug 12, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Diagnostic approaches for detecting deep vein thrombosis
1Division of Vascular Surgery, University of Washington School of Medicine, Seattle.
Insights
Confirming acute deep vein thrombosis requires objective testing. Ultrasonic duplex scanning offers high accuracy (90-100%) for diagnosing deep vein thrombosis from the vena cava to below the knee.
Area of Science:
- Vascular Medicine
- Diagnostic Imaging
Background:
- Acute deep vein thrombosis (DVT) diagnosis necessitates objective confirmation.
- Current methods like Doppler and impedance plethysmography have limitations, especially below the knee.
Purpose of the Study:
- To evaluate the diagnostic performance of ultrasonic duplex scanning for acute deep vein thrombosis.
- To compare duplex scanning with other diagnostic modalities for DVT.
Main Methods:
- Utilized continuous-wave Doppler, impedance plethysmography, and ultrasonic duplex scanning.
- Duplex scanning assessed thrombus visualization, vein compressibility, and venous blood flow.
- Diagnostic accuracy was determined using sensitivity and specificity metrics.
Main Results:
- Duplex scanning demonstrated high sensitivity and specificity (90-100%) for DVT detection.
- Limitations of Doppler and plethysmography include inability to assess distal DVT accurately.
- False positives with duplex scanning were noted in iliac and superficial femoral veins; false negatives in calf veins.
Conclusions:
- Ultrasonic duplex scanning is a highly accurate method for diagnosing deep vein thrombosis throughout the venous system.
- Duplex scanning provides superior anatomical detail and diagnostic confidence compared to Doppler and plethysmography.
- Careful application of diagnostic criteria is essential to minimize false positives and negatives in specific venous segments.
Abstract:
Acute deep vein thrombosis remains a disease for which the diagnosis must be confirmed by an objective testing procedure. The current methods in use include continuous-wave Doppler, impedance plethysmography, and ultrasonic duplex scanning. The Doppler and plethysmographic methods are of value for the detection of proximal venous occlusion but do have limitations below the knee and fail to provide specific information concerning the exact location and extent of involvement. Duplex scanning, which has both imaging and flow detection capabilities, can be used from the level of the inferior vena cava to below the knee. When duplex scanning is used, the following variables are used in arriving at a diagnosis: visualization of the thrombus, lack of compressibility of the vein, and the absence of spontaneous and phasic flow from the large veins. When all of these variables are used in the screening process, the sensitivity and specificity will be in the range of 90% to 100%. Most false-positive results occur when the incompressibility variable is attempted for the iliac veins and the superficial femoral vein in the adductor canal. The majority of false negatives will be related to missed thrombi in the small veins of the calf.
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